Transport for London have begun work on the A2 Rochester Way at the Danson interchange.
Upgrades are planned near the junction leading off towards Bexleyheath with an overpass seeing extensive work undertaken. Roadworks are expected to last at least five months.
Work got underway this past week with traffic towards Kent backing up as lanes are closed.
TfL warn bus routes serving the area such as the B15 could be disrupted.