Retailer B&M have submitted plans to open in Thamesmead at the former Wilko store.
The unit at Cannon Retail park has sat empty for a while. The company also have branches at Charlton and Kidbrooke.
The retail park has struggled for some time with not only the loss of Wilko but also Argos previously.
An express bus from Bromley will start in 2024 and terminate in the area, while long term there are plans for an express bus to Woolwich and a possible DLR station in this area.
The planning application can be viewed here.